Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Formulation and Evaluation of Bioadhesive Cyproheptadine Tablets

V V Chandrakala² , M S Srinath¹, Saral A Mary², Kumar S Utpal²

¹Department of Pharmaceutics, Government College of Pharmacy, Bangalore, Pharmaceutical Chemistry Division; ²School of Science and Humanities, Vellore Institute of Technology, Vellore, Tamil Nadu, India.

For correspondence:- V Chandrakala Email: chandrakalav@yahoo.com Tel:+918025456581

Received: 4 August 2010 Accepted: 5 May 2011 Published: 20 August 2011

Citation: Chandrakala VV, Srinath MS, Mary SA, Utpal KS. Formulation and Evaluation of Bioadhesive Cyproheptadine Tablets. Trop J Pharm Res 2011; 10(4):365-373 doi: 10.4314/tjpr.v10i4.1

© 2011 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the effect of formulation variables on the bioadhesion and release properties of bioadhesive cyproheptadine hydrochloride tablets.

Methods: Screening of polymers - hydroxypropyl methylcellulose, (HPMC), sodium carboxy methyl cellulose (CMC), and Carbopol 974p and 934p - in solution form were carried out by shear stress and detachment force measurement,based on Taguchi model, in order to determine their bioadhesion properties. Central composite design (CCD) was applied to optimize the combined effects of the polymers on release rate constant (K), diffusion coefficient (n), regression coefficient (R²) and detachment force of a sustained release tablet formulation of cyproheptadine hydrochloride containing also a prompt dose of the drug.

Results: The shear stress of 3 % solution of HPMC was greater than that of an equivalent concentration of Carbopol 934P. The values of K, n, R²and detachment force for the optimized formulation (F0) were 0.269, 0.696, 0.964 and 0.066 Newton (N), respectively, and showed good correlation with the predicted values, thus confirming the practicability and validity of the model.

Conclusion: Gastric retention time can be increased for cyproheptadine hydrochloride by formulating it as a bioadhesive tablet that enhances the retention of the dosage form in the stomach and hence gastric absorption of the drug.

Keywords: Cyproheptadine hydrochloride, Bioadhesive core tablet, Detachment force, Taguchi design, Central composite design